Babesia gibsoni: Identification of an immunodominant, interspersed repeat antigen
In this report, an immunodominant antigen called BgIRA from Babesia gibsoni is identified and described. A highly repetitive antigen was screened from a cDNA library. The genomic BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs...
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| Veröffentlicht in: | Experimental parasitology 2008, Vol.118 (1), p.146-149 |
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| container_title | Experimental parasitology |
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| creator | Jia, Honglin Terkawi, M. Alaa Aboge, Gabriel Oluga Goo, Youn-Kyoung Zhou, Jinlin Lee, Eung-Goo Nishikawa, Yoshifumi Igarashi, Ikuo Fujisaki, Kozo Xuan, Xuenan |
| description | In this report, an immunodominant antigen called BgIRA from
Babesia gibsoni is identified and described. A highly repetitive antigen was screened from a cDNA library. The genomic
BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs infected with
B. gibsoni. The specificity and sensitivity of the rBgIRA in an ELISA indicated that this antigen might be useful in a diagnostic test. |
| doi_str_mv | 10.1016/j.exppara.2007.07.005 |
| format | Article |
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Babesia gibsoni is identified and described. A highly repetitive antigen was screened from a cDNA library. The genomic
BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs infected with
B. gibsoni. The specificity and sensitivity of the rBgIRA in an ELISA indicated that this antigen might be useful in a diagnostic test.</description><identifier>ISSN: 0014-4894</identifier><identifier>EISSN: 1090-2449</identifier><identifier>DOI: 10.1016/j.exppara.2007.07.005</identifier><identifier>PMID: 17870070</identifier><identifier>CODEN: EXPAAA</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Animals ; Antibodies, Protozoan - biosynthesis ; Antigens, Protozoan - genetics ; Antigens, Protozoan - immunology ; Antigens, Protozoan - isolation & purification ; Babesia - genetics ; Babesia - immunology ; Babesia gibsoni ; Babesiosis - diagnosis ; Babesiosis - immunology ; Babesiosis - veterinary ; Base Sequence ; BgIRA ; Biological and medical sciences ; Blotting, Southern ; Blotting, Western ; Dog Diseases - diagnosis ; Dog Diseases - immunology ; Dogs ; ELISA ; Enzyme-Linked Immunosorbent Assay - veterinary ; Fundamental and applied biological sciences. Psychology ; Gene Library ; Immunodominant Epitopes - genetics ; Immunodominant Epitopes - immunology ; Immunodominant Epitopes - isolation & purification ; Life cycle. Host-agent relationship. Pathogenesis ; Molecular Sequence Data ; Protozoa ; Sensitivity and Specificity ; Specific Pathogen-Free Organisms</subject><ispartof>Experimental parasitology, 2008, Vol.118 (1), p.146-149</ispartof><rights>2007 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-d4dbf60ada42f6bb2f7b7a20736e202e7126e1c0e7853eb4ba0a6719e81bf1603</citedby><cites>FETCH-LOGICAL-c424t-d4dbf60ada42f6bb2f7b7a20736e202e7126e1c0e7853eb4ba0a6719e81bf1603</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.exppara.2007.07.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19984263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17870070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Honglin</creatorcontrib><creatorcontrib>Terkawi, M. Alaa</creatorcontrib><creatorcontrib>Aboge, Gabriel Oluga</creatorcontrib><creatorcontrib>Goo, Youn-Kyoung</creatorcontrib><creatorcontrib>Zhou, Jinlin</creatorcontrib><creatorcontrib>Lee, Eung-Goo</creatorcontrib><creatorcontrib>Nishikawa, Yoshifumi</creatorcontrib><creatorcontrib>Igarashi, Ikuo</creatorcontrib><creatorcontrib>Fujisaki, Kozo</creatorcontrib><creatorcontrib>Xuan, Xuenan</creatorcontrib><title>Babesia gibsoni: Identification of an immunodominant, interspersed repeat antigen</title><title>Experimental parasitology</title><addtitle>Exp Parasitol</addtitle><description>In this report, an immunodominant antigen called BgIRA from
Babesia gibsoni is identified and described. A highly repetitive antigen was screened from a cDNA library. The genomic
BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs infected with
B. gibsoni. The specificity and sensitivity of the rBgIRA in an ELISA indicated that this antigen might be useful in a diagnostic test.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies, Protozoan - biosynthesis</subject><subject>Antigens, Protozoan - genetics</subject><subject>Antigens, Protozoan - immunology</subject><subject>Antigens, Protozoan - isolation & purification</subject><subject>Babesia - genetics</subject><subject>Babesia - immunology</subject><subject>Babesia gibsoni</subject><subject>Babesiosis - diagnosis</subject><subject>Babesiosis - immunology</subject><subject>Babesiosis - veterinary</subject><subject>Base Sequence</subject><subject>BgIRA</subject><subject>Biological and medical sciences</subject><subject>Blotting, Southern</subject><subject>Blotting, Western</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - immunology</subject><subject>Dogs</subject><subject>ELISA</subject><subject>Enzyme-Linked Immunosorbent Assay - veterinary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Library</subject><subject>Immunodominant Epitopes - genetics</subject><subject>Immunodominant Epitopes - immunology</subject><subject>Immunodominant Epitopes - isolation & purification</subject><subject>Life cycle. Host-agent relationship. Pathogenesis</subject><subject>Molecular Sequence Data</subject><subject>Protozoa</subject><subject>Sensitivity and Specificity</subject><subject>Specific Pathogen-Free Organisms</subject><issn>0014-4894</issn><issn>1090-2449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMGKFDEQhoMo7rj6CEpf9GSPlUy60-1FdNnVhQUR9BwqSfWSYTppk4zo25thGva4UEVdvr-q-Bh7zWHLgfcf9lv6uyyYcCsA1PZU0D1hGw4jtELK8SnbAHDZymGUF-xFznsAGLiQz9kFV4OqKdiwH1_QUPbY3HuTY_Afm1tHofjJWyw-hiZODYbGz_MxRBdnHzCU940PhVJeapNrEi2EpWLF31N4yZ5NeMj0ap2X7NfN9c-rb-3d96-3V5_vWiuFLK2Tzkw9oEMppt4YMSmjUIDa9SRAkOKiJ26B1NDtyEiDgL3iIw3cTLyH3SV7d967pPj7SLno2WdLhwMGisesVbU09J16FKw3lRzUUMHuDNoUc0406SX5GdM_zUGfpOu9XqXrk3R9Kuhq7s164Ghmcg-p1XIF3q4AZouHKWGwPj9w4zhI0e8q9-nMUfX2x1PS2XoKlpxPZIt20T_yyn8xNKMy</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Jia, Honglin</creator><creator>Terkawi, M. Alaa</creator><creator>Aboge, Gabriel Oluga</creator><creator>Goo, Youn-Kyoung</creator><creator>Zhou, Jinlin</creator><creator>Lee, Eung-Goo</creator><creator>Nishikawa, Yoshifumi</creator><creator>Igarashi, Ikuo</creator><creator>Fujisaki, Kozo</creator><creator>Xuan, Xuenan</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Babesia gibsoni: Identification of an immunodominant, interspersed repeat antigen</title><author>Jia, Honglin ; Terkawi, M. Alaa ; Aboge, Gabriel Oluga ; Goo, Youn-Kyoung ; Zhou, Jinlin ; Lee, Eung-Goo ; Nishikawa, Yoshifumi ; Igarashi, Ikuo ; Fujisaki, Kozo ; Xuan, Xuenan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-d4dbf60ada42f6bb2f7b7a20736e202e7126e1c0e7853eb4ba0a6719e81bf1603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibodies, Protozoan - biosynthesis</topic><topic>Antigens, Protozoan - genetics</topic><topic>Antigens, Protozoan - immunology</topic><topic>Antigens, Protozoan - isolation & purification</topic><topic>Babesia - genetics</topic><topic>Babesia - immunology</topic><topic>Babesia gibsoni</topic><topic>Babesiosis - diagnosis</topic><topic>Babesiosis - immunology</topic><topic>Babesiosis - veterinary</topic><topic>Base Sequence</topic><topic>BgIRA</topic><topic>Biological and medical sciences</topic><topic>Blotting, Southern</topic><topic>Blotting, Western</topic><topic>Dog Diseases - diagnosis</topic><topic>Dog Diseases - immunology</topic><topic>Dogs</topic><topic>ELISA</topic><topic>Enzyme-Linked Immunosorbent Assay - veterinary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Library</topic><topic>Immunodominant Epitopes - genetics</topic><topic>Immunodominant Epitopes - immunology</topic><topic>Immunodominant Epitopes - isolation & purification</topic><topic>Life cycle. Host-agent relationship. Pathogenesis</topic><topic>Molecular Sequence Data</topic><topic>Protozoa</topic><topic>Sensitivity and Specificity</topic><topic>Specific Pathogen-Free Organisms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jia, Honglin</creatorcontrib><creatorcontrib>Terkawi, M. Alaa</creatorcontrib><creatorcontrib>Aboge, Gabriel Oluga</creatorcontrib><creatorcontrib>Goo, Youn-Kyoung</creatorcontrib><creatorcontrib>Zhou, Jinlin</creatorcontrib><creatorcontrib>Lee, Eung-Goo</creatorcontrib><creatorcontrib>Nishikawa, Yoshifumi</creatorcontrib><creatorcontrib>Igarashi, Ikuo</creatorcontrib><creatorcontrib>Fujisaki, Kozo</creatorcontrib><creatorcontrib>Xuan, Xuenan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental parasitology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Honglin</au><au>Terkawi, M. Alaa</au><au>Aboge, Gabriel Oluga</au><au>Goo, Youn-Kyoung</au><au>Zhou, Jinlin</au><au>Lee, Eung-Goo</au><au>Nishikawa, Yoshifumi</au><au>Igarashi, Ikuo</au><au>Fujisaki, Kozo</au><au>Xuan, Xuenan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Babesia gibsoni: Identification of an immunodominant, interspersed repeat antigen</atitle><jtitle>Experimental parasitology</jtitle><addtitle>Exp Parasitol</addtitle><date>2008</date><risdate>2008</risdate><volume>118</volume><issue>1</issue><spage>146</spage><epage>149</epage><pages>146-149</pages><issn>0014-4894</issn><eissn>1090-2449</eissn><coden>EXPAAA</coden><abstract>In this report, an immunodominant antigen called BgIRA from
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BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs infected with
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| subjects | Amino Acid Sequence Animals Antibodies, Protozoan - biosynthesis Antigens, Protozoan - genetics Antigens, Protozoan - immunology Antigens, Protozoan - isolation & purification Babesia - genetics Babesia - immunology Babesia gibsoni Babesiosis - diagnosis Babesiosis - immunology Babesiosis - veterinary Base Sequence BgIRA Biological and medical sciences Blotting, Southern Blotting, Western Dog Diseases - diagnosis Dog Diseases - immunology Dogs ELISA Enzyme-Linked Immunosorbent Assay - veterinary Fundamental and applied biological sciences. Psychology Gene Library Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Immunodominant Epitopes - isolation & purification Life cycle. Host-agent relationship. Pathogenesis Molecular Sequence Data Protozoa Sensitivity and Specificity Specific Pathogen-Free Organisms |
| title | Babesia gibsoni: Identification of an immunodominant, interspersed repeat antigen |
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