Babesia gibsoni: Identification of an immunodominant, interspersed repeat antigen

In this report, an immunodominant antigen called BgIRA from Babesia gibsoni is identified and described. A highly repetitive antigen was screened from a cDNA library. The genomic BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental parasitology 2008, Vol.118 (1), p.146-149
Hauptverfasser:	Jia, Honglin, Terkawi, M. Alaa, Aboge, Gabriel Oluga, Goo, Youn-Kyoung, Zhou, Jinlin, Lee, Eung-Goo, Nishikawa, Yoshifumi, Igarashi, Ikuo, Fujisaki, Kozo, Xuan, Xuenan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Protozoan - biosynthesis Antigens, Protozoan - genetics Antigens, Protozoan - immunology Antigens, Protozoan - isolation & purification Babesia - genetics Babesia - immunology Babesia gibsoni Babesiosis - diagnosis Babesiosis - immunology Babesiosis - veterinary Base Sequence BgIRA Biological and medical sciences Blotting, Southern Blotting, Western Dog Diseases - diagnosis Dog Diseases - immunology Dogs ELISA Enzyme-Linked Immunosorbent Assay - veterinary Fundamental and applied biological sciences. Psychology Gene Library Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Immunodominant Epitopes - isolation & purification Life cycle. Host-agent relationship. Pathogenesis Molecular Sequence Data Protozoa Sensitivity and Specificity Specific Pathogen-Free Organisms
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In this report, an immunodominant antigen called BgIRA from Babesia gibsoni is identified and described. A highly repetitive antigen was screened from a cDNA library. The genomic BgIRA gene exists as single cope gene and contains 10 introns. BgIRA plays a dominant role in the immune response in dogs infected with B. gibsoni. The specificity and sensitivity of the rBgIRA in an ELISA indicated that this antigen might be useful in a diagnostic test.
ISSN:	0014-4894 1090-2449
DOI:	10.1016/j.exppara.2007.07.005