The evidence for using conjugate vaccines to protect HIV-infected children against pneumococcal disease
Summary Pneumococcal conjugate vaccines (PCVs) are a potentially useful complement to existing treatment strategies in HIV-infected children, for whom pneumococcal infections are common and serious. This Review summarises available data on the burden of pneumococcal disease and the safety and effica...
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Veröffentlicht in: | The Lancet infectious diseases 2008, Vol.8 (1), p.67-80 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Summary Pneumococcal conjugate vaccines (PCVs) are a potentially useful complement to existing treatment strategies in HIV-infected children, for whom pneumococcal infections are common and serious. This Review summarises available data on the burden of pneumococcal disease and the safety and efficacy of PCVs in HIV-infected children. The data demonstrate that children with HIV have significantly increased risk of pneumococcal disease compared with uninfected children; the serotypes included in currently licensed or near-licensure conjugate vaccines include most serotypes that cause invasive pneumococcal disease (IPD) in HIV-infected children and adults; PCVs provide substantial protection against IPD and clinical pneumonia when given to HIV-infected infants; and HIV-infected adults gain an indirect benefit when children in the community are vaccinated. PCV should be considered as an important intervention for improving the lives of HIV-infected children. |
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ISSN: | 1473-3099 1474-4457 |
DOI: | 10.1016/S1473-3099(07)70242-6 |