Elevated cyclooxygenase-2 expression is associated with histological grade in invasive ductal breast carcinoma

Purpose: The aim of this study was to evaluatethe expression of cyclooxygenase-2 in humanbreast cancer using immunohistochemistry and todetermine whether the expression of cyclooxygenase-2 is associated with clinicopathological factorsin invasive ductal breast carcinoma.Methods: Cyclooxygenase-2 exp...

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Veröffentlicht in:	Journal of Medical and Dental Sciences 2005, Vol.52(4), pp.189-193
Hauptverfasser:	Takeshita, Emiko, Osanai, Takayuki, Higuchi, Tetsuro, Soumaoro, Labile Togba, Sugihara, Kenichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - pathology Adenocarcinoma, Scirrhous - enzymology Adenocarcinoma, Scirrhous - pathology Adult Age Factors Aged breast carcinoma Breast Neoplasms - enzymology Breast Neoplasms - pathology Carcinoma, Ductal, Breast - enzymology Carcinoma, Ductal, Breast - pathology Carcinoma, Papillary - enzymology Carcinoma, Papillary - pathology Cyclooxygenase 2 - analysis cyclooxygenase-2 Dentistry Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic histological grade Humans Immunohistochemistry Lymph Nodes - pathology Middle Aged Receptors, Estrogen - analysis Receptors, Progesterone - analysis
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Zusammenfassung:	Purpose: The aim of this study was to evaluatethe expression of cyclooxygenase-2 in humanbreast cancer using immunohistochemistry and todetermine whether the expression of cyclooxygenase-2 is associated with clinicopathological factorsin invasive ductal breast carcinoma.Methods: Cyclooxygenase-2 expression wasinvestigated by immunohistochemistry in 30 invasiveductal breast carcinoma specimens and relationshipsbetween cyclooxygenase-2 expressionand age, histological grade, histological type,nodal status, and hormone receptor status wereevaluated.Results: Cyclooxygenase-2 expression wasfound in 56.7% of the tumor samples and was relatedto histological grade (P
ISSN:	1342-8810 2185-9132
DOI:	10.11480/jmds.520404