The susceptibility of anaerobic bacteria isolated from periodontal diseases to photodynamic inactivation with Fotolon (chlorin e6)

Photodynamic inactivation (PDI) may be a very promising alternative method for the antimicrobial treatment of periodontitis. Several studies have demonstrated the sensitivity of subgingival flora to PDI using toluidine blue, methylene blue, and chlorin e6 derivatives. In the present study we report...

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Veröffentlicht in:	Polish journal of microbiology 2005, Vol.54 (4), p.305-310
Hauptverfasser:	Drulis-Kawa, Zuzanna, Bednarkiewicz, Artur, Bugla-Płoskonska, Gabriela, Strek, Wiesław, Doroszkiewicz, Włodzimierz
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobic bacteria Bacteria, Anaerobic - drug effects Bacteria, Anaerobic - isolation & purification Gram-Negative Anaerobic Bacteria - drug effects Gram-Negative Anaerobic Bacteria - isolation & purification Gram-Positive Bacteria - drug effects Gram-Positive Bacteria - isolation & purification Humans In Vitro Techniques Inactivation Periodontal diseases Periodontal Diseases - drug therapy Periodontal Diseases - microbiology Photochemotherapy Photosensitizing Agents - pharmacology Porphyrins - pharmacology
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Zusammenfassung:	Photodynamic inactivation (PDI) may be a very promising alternative method for the antimicrobial treatment of periodontitis. Several studies have demonstrated the sensitivity of subgingival flora to PDI using toluidine blue, methylene blue, and chlorin e6 derivatives. In the present study we report the activity of the Fotolon sensitizer, composed of chlorin e6 and polyvinylpyrrolidone (PVP), against anaerobic bacteria isolated from periodontal diseases. Over 99.9% reduction in colony forming units in 20 Gram-positive and 30 Gram-negative clinical anaerobic strains was obtained.
ISSN:	1733-1331 2544-4646