Compression and free expansion of single DNA molecules in nanochannels

We investigated compression and ensuing expansion of long DNA molecules confined in nanochannels. Transverse confinement of DNA molecules in the nanofluidic channels leads to elongation of their unconstrained equilibrium configuration. The extended molecules were compressed by electrophoretically dr...

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Veröffentlicht in:	Physical review letters 2005-12, Vol.95 (26), p.268101.1-268101.4, Article 268101
Hauptverfasser:	RECCIUS, Christian Hermann, MANNION, John Thomas, CROSS, Joshua David, CRAIGHEAD, H. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Compressive Strength Computer Simulation DNA - chemistry DNA - ultrastructure Elasticity Electrophoresis - methods Fundamental and applied biological sciences. Psychology General aspects, investigation methods Microfluidic Analytical Techniques - methods Micromanipulation - methods Models, Chemical Models, Molecular Nanotechnology - methods Nucleic Acid Conformation Nucleic acids Stress, Mechanical
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