[ [formula omitted]]Rilmenidine-labelled imidazoline-receptor binding sites co-localize with [ [formula omitted]]2-(benzofuranyl)-2-imidazoline-labelled imidazoline-receptor binding sites and monoamine oxidase-B in rabbit, but not rat, kidney

The distribution and relative densities of imidazoline-receptor binding sites (I-RBS) and monoamine oxidase (MAO)-A and -B enzyme(s) in rat and rabbit kidney were compared autoradiographically using fixed nanomolar concentrations of [ 3 H ]rilmenidine and [ 3 H ]2-(benzofuranyl)-2-imidazoline ([ 3 H ]2-BFI) to label I-RBS, and [ 3 H ]RO41-1049 and [ 3 H ]RO19-6327 to label MAO-A and -B isoenzymes, respectively. In rat kidney, high densities of I-RBS labelled by [ 3 H ]rilmenidine were observed in the cortex and outer stripe (120–280 fmol/mg tissue), in contrast to low I-RBS densities labelled by [ 3 H ]2-BFI (