Expression of genes for thioredoxin 1 and thioredoxin 2 in multidrug resistance ovarian carcinoma cells SKVLB

The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 ge...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2007-09, Vol.144 (3), p.301-303
Hauptverfasser:	Kalinina, E V, Chernov, N N, Saprin, A N, Kotova, Y N, Gavrilova, Y A, Chermnykh, N S, Shcherbak, N P
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Female Gene Expression Regulation, Enzymologic Humans Isoenzymes - genetics Isoenzymes - metabolism Ovarian Neoplasms - genetics Thioredoxins - genetics Thioredoxins - metabolism
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Zusammenfassung:	The expression of genes for thioredoxin isoforms Trx1 and Trx2 was studied in sensitive SKOV-3 and resistant SKVLB human ovarian carcinoma cells. The development of doxorubicin resistance was accompanied by a significant increase in the expression of TRX1 gene and less pronounced increase in TRX2 gene expression.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-007-0316-3