Study of bipathic effect of phenazepam

Phenazepam in ultralow doses significantly potentiated anxiolytic and anticonvulsant effects of therapeutic doses of the same drug both after preliminary or simultaneous administration, which attests to bipathic action of phenazepam. The combination of ultralow and therapeutic doses of phenazepam pr...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2007-10, Vol.144 (4), p.536-538
Hauptverfasser:	Epstein, O I, Voronina, T A, Molodavkin, G M, Belopol'skaya, M V, Kheyfets, I A, Dugina, J L, Sergeeva, S A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Anticonvulsants - pharmacology Benzodiazepines - pharmacology Dose-Response Relationship, Drug Drinking - drug effects Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - pharmacology Male Motor Activity - drug effects Random Allocation Rats
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Zusammenfassung:	Phenazepam in ultralow doses significantly potentiated anxiolytic and anticonvulsant effects of therapeutic doses of the same drug both after preliminary or simultaneous administration, which attests to bipathic action of phenazepam. The combination of ultralow and therapeutic doses of phenazepam prevented the development of its specific myorelaxant and sedative side effects.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-007-0371-9