Parasympathetic cardiac effects in sympathectomized rats

In adult sympathectomized rats the right and left vagus nerves exhibited asymmetric effects on heart rate and strength of cardiac contractions. After vagotomy, the heart rate and stroke volume remained high in sympathectomized rats, but returned to normal in intact animals. The sympathetic nervous s...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2007-08, Vol.144 (2), p.166-170
Hauptverfasser:	Gizzatullin, A R, Gilmutdinova, R I, Minnahmetov, R R, Sitdikov, F G, Chiglintcev, V M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Electric Stimulation Female Heart - drug effects Heart - innervation Heart - physiology Heart Rate - physiology Male Myocardial Contraction - physiology Parasympathetic Nervous System - physiology Propranolol - pharmacology Rats Sympathectomy, Chemical Sympathetic Nervous System - physiology Vagotomy Vagus Nerve - physiology
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Zusammenfassung:	In adult sympathectomized rats the right and left vagus nerves exhibited asymmetric effects on heart rate and strength of cardiac contractions. After vagotomy, the heart rate and stroke volume remained high in sympathectomized rats, but returned to normal in intact animals. The sympathetic nervous system plays a role in postvagotomic tachycardia. Sympathectomized rats were characterized by higher reactivity of cardiac beta-adrenoceptors to propranolol compared to intact animals.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-007-0280-y