Lichenicolins A and B, new bisnaphthopyrones from an unidentified lichenicolous fungus, strain LL-RB0668

Lichenicolous fungus LL-RB0668 was isolated from a processed lichen thallus on a modified Lilly-Barnett solid medium. Two new bisnaphthopyrone compounds, lichenicolins A (1) and B (2), were isolated from the culture broth of this organism fermented on a rice-based solid medium. These results demonst...

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Veröffentlicht in:	Journal of antibiotics 2005-11, Vol.58 (11), p.731-736
Hauptverfasser:	He, Haiyin, Bigelis, Ramunas, Yang, Hui Y, Chang, Li-Ping, Singh, Maya P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Candida albicans - drug effects Culture Media - chemistry Fermentation Fungi - isolation & purification Fungi - metabolism Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Lichens Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Molecular Structure Pyrones - chemistry Pyrones - isolation & purification Pyrones - pharmacology Thallus
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Beschreibung
Zusammenfassung:	Lichenicolous fungus LL-RB0668 was isolated from a processed lichen thallus on a modified Lilly-Barnett solid medium. Two new bisnaphthopyrone compounds, lichenicolins A (1) and B (2), were isolated from the culture broth of this organism fermented on a rice-based solid medium. These results demonstrate that lichen-associated fungi potentially are a good resource for new bioactive natural products for current screening programs.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2005.99