Methods for selection of aptamers to protein targets

Methods for selection of aptamers to protein targets

Aptamers are synthetic single-stranded RNA or DNA molecules capable of specific binding to other target molecules. In this review, the main aptamer properties are considered and methods for selection of aptamers against various protein targets are described. Special attention is given to the methods...

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Veröffentlicht in:Biochemistry (Moscow) 2007-12, Vol.72 (13), p.1505-1518
1. Verfasser: Kulbachinskiy, A V
Format: Artikel
Sprache:eng
Schlagworte:
Aptamers, Nucleotide - chemistry
Combinatorial Chemistry Techniques
Deoxyribonucleic acid
DNA
DNA, Single-Stranded - chemistry
Epitopes
Gene Library
Genetic Techniques
Ligands
Methods
Oligonucleotides - chemistry
Proteins
Proteins - chemistry
RNA - chemistry
Selection, Genetic
SELEX Aptamer Technique - methods
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Beschreibung
Zusammenfassung:Aptamers are synthetic single-stranded RNA or DNA molecules capable of specific binding to other target molecules. In this review, the main aptamer properties are considered and methods for selection of aptamers against various protein targets are described. Special attention is given to the methods for directed selection of aptamers, which allow one to obtain ligands with specified properties.
ISSN:0006-2979
1608-3040
0320-9725
DOI:10.1134/s000629790713007x