Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1)

GPR40 is G protein-coupled receptor whose endogenous ligands have recently been identified as free fatty acids (FFAs), and it has been implicated to play an important role in FFA-mediated enhancement of glucose-stimulated insulin release. We have developed a monoclonal antibody against the extracell...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-01, Vol.365 (1), p.22-28
Hauptverfasser:	Hirasawa, Akira, Itsubo, Chisato, Sadakane, Keiko, Hara, Takafumi, Shinagawa, Shingo, Koga, Hanako, Nose, Hiroshi, Koshimizu, Taka-aki, Tsujimoto, Gozoh
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibody Specificity Cells, Cultured Flow cytometry Free fatty acid receptor 1 GPR40 Humans Immunohistochemistry Leukocytes, Mononuclear - metabolism Mice Molecular Sequence Data Monoclonal antibody Monocytes Peptide Fragments - metabolism Receptors, G-Protein-Coupled - analysis Receptors, G-Protein-Coupled - immunology THP-1 cell Transfection
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