Identification of Phoslactomycin E as a Metabolite Inducing Hyphal Morphological Abnormalities in Aspergillus fumigatus IFO 5840

In our survey for antifungal compounds, a fermentation broth of Streptomyces sp. HA81-2 was found to inhibit the in vitro growth of Aspergillus fumigatus IFO 5840 accompanied by hyphal morphological abnormalities. One of the isolated antibiotics was identified as phoslactomycin E based on LC-MS and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 2007-12, Vol.60 (12), p.762-765
Hauptverfasser:	Mizuhara, Naoko, Usuki, Yoshinosuke, Ogita, Masaki, Fujita, Ken-Ichi, Kuroda, Manabu, Doe, Matsumi, Iio, Hideo, Tanaka, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Aspergillus fumigatus Aspergillus fumigatus - cytology Aspergillus fumigatus - drug effects Aspergillus fumigatus - growth & development Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Chromatography, Liquid communication-to-the-editor Culture Media - chemistry Fermentation Fungal Proteins - antagonists & inhibitors Glucosyltransferases - antagonists & inhibitors Hyphae - cytology Hyphae - drug effects Lactones - chemistry Lactones - isolation & purification Lactones - pharmacology Life Sciences Magnetic Resonance Spectroscopy Mass Spectrometry Medicinal Chemistry Metabolites Microbiology Molecular Structure Organic Chemistry Organophosphorus Compounds - chemistry Organophosphorus Compounds - isolation & purification Organophosphorus Compounds - pharmacology Streptomyces Streptomyces - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In our survey for antifungal compounds, a fermentation broth of Streptomyces sp. HA81-2 was found to inhibit the in vitro growth of Aspergillus fumigatus IFO 5840 accompanied by hyphal morphological abnormalities. One of the isolated antibiotics was identified as phoslactomycin E based on LC-MS and NMR spectral data. In a preliminary assay using the membrane fractions of A. fumigatus , phoslactomycin E was found to inhibit the activity of 1,3-β glucan synthase.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2007.101