Effect of Prostaglandin E1 on Cerebral Blood Flow in Patients with Chronic Cerebral Infarction

The effect of prostaglandin E1 (PCE1 on cerebral blood flow (CBF) was studied in 10 patients with chronic cerebral infarction. Regional cerebral blood flow (rCBF) was measured by single photon emission computed tomography before and after they received PGE1 120 μg daily for 2 weeks. The rCBF of the...

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Veröffentlicht in:	Internal Medicine 1998, Vol.37(10), pp.841-846
Hauptverfasser:	KOMABA, Yuichi, KITAMURA, Shin, TERASHI, Akiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alprostadil - administration & dosage Alprostadil - pharmacology Alprostadil - therapeutic use Biological and medical sciences Brain - blood supply Cardiovascular system Cerebral Infarction - diagnostic imaging Cerebral Infarction - drug therapy Cerebral Infarction - physiopathology Cerebrovascular Circulation - drug effects Chronic Disease Drug Evaluation Female Humans Infusions, Intravenous intracerebral steal phenomenon Male Medical sciences Pharmacology. Drug treatments Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use single photon emission computed tomography Stimulation, Chemical Tomography, Emission-Computed, Single-Photon Vasodilator Agents - administration & dosage Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Vasodilator agents. Cerebral vasodilators
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Zusammenfassung:	The effect of prostaglandin E1 (PCE1 on cerebral blood flow (CBF) was studied in 10 patients with chronic cerebral infarction. Regional cerebral blood flow (rCBF) was measured by single photon emission computed tomography before and after they received PGE1 120 μg daily for 2 weeks. The rCBF of the brainstem, cerebellum, and frontal, temporal, and parietal lobes increased significantly after PGE1 administration. PGE1 also significantly increased the rCBF of the non-infarcted area adjacent to infarction. The results indicate that PGE1 increases the CBF of patients with chronic cerebral infarction without causing the intracerebral steal phenomenon. (Internal Medicine 37: 841-846, 1998)
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.37.841