Polymorphism of the vWA locus located in the center of the three vWA STRs in the Japanese population

Polymorphism of the vWA locus located in the center of the three vWA STRs in the Japanese population

Abstract The structural polymorphism of the vWA locus (vWA-T) located between the two polymorphic vWA loci (vWA-K and -P) was analyzed in 100 Japanese individuals using DNA samples isolated from dental pulp. The polymorphism of this locus was based on the difference in the number of tcta repeat. New...

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Veröffentlicht in:Legal medicine (Tokyo, Japan) Japan), 2008-01, Vol.10 (1), p.31-34
Hauptverfasser: Tsutsumi, Hirofumi, Komuro, Toshinobu, Mukoyama, Rei, Nogami, Hiroaki
Format: Artikel
Sprache:eng
Schlagworte:
Asian Continental Ancestry Group - genetics
Dental pulp
Electrophoresis, Polyacrylamide Gel
Forensic odontology
Gene Frequency
Genetics, Population
Genotype
Humans
Internal Medicine
Japan
Polymerase Chain Reaction
Polymorphism, Genetic
Repeat structure
Tandem Repeat Sequences
von Willebrand Factor - genetics
vWA
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Zusammenfassung:Abstract The structural polymorphism of the vWA locus (vWA-T) located between the two polymorphic vWA loci (vWA-K and -P) was analyzed in 100 Japanese individuals using DNA samples isolated from dental pulp. The polymorphism of this locus was based on the difference in the number of tcta repeat. New interallele 11.1 was found in two samples. All together 9 alleles and 19 genotypes were observed. In addition, one mutant allele contained tcga in the common tcta repeat structure. The value of PD was calculated to be 0.900. Inheritance of the polymorphism was confirmed in a family including 23 individuals and 6 matings.
ISSN:1344-6223
1873-4162
DOI:10.1016/j.legalmed.2007.05.008