Heterozygosity for Interleukin-18 -607 A/C Polymorphism is Associated with Risk for Colorectal Cancer

Heterozygosity for Interleukin-18 -607 A/C Polymorphism is Associated with Risk for Colorectal Cancer

Background: The possible contribution of interleukin-18 (IL-18) -607 A/C polymorphism towards the development of colorectal cancer was investigated. Patients and Methods: DNA samples of 84 patients with colorectal cancer (adenocarcinomas) and 89 healthy controls were examined by allele-specific poly...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Anticancer research 2007-11, Vol.27 (6B), p.3849-3853
Hauptverfasser: NIKITEAS, Nikolaos, YANNOPOULOS, Athanasios, CHATZITHEOFYLAKTOU, Agapi, TSIGRIS, Christos
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - genetics
Adenocarcinoma - pathology
Alleles
Biological and medical sciences
Case-Control Studies
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Genetic Predisposition to Disease
Genotype
Heterozygote
Humans
Interleukin-18 - genetics
Medical sciences
Neoplasm Staging
Polymorphism, Genetic
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background: The possible contribution of interleukin-18 (IL-18) -607 A/C polymorphism towards the development of colorectal cancer was investigated. Patients and Methods: DNA samples of 84 patients with colorectal cancer (adenocarcinomas) and 89 healthy controls were examined by allele-specific polymerase chain reaction followed by electrophoretic analysis. The resulting allele and genotype frequencies of patients were compared to those of the respective controls using Fischer's exact test and odds ratios. Results: The proportion of heterozygotes in the patient group was significantly higher than that in healthy controls (p
ISSN:0250-7005
1791-7530