Structural and functional changes in myocardial thin filaments in experimental hypothyrosis

Fluorescence resonance energy transfer study revealed decreased intermonomer mobility of Ca-actin and Mg-actin filaments of myocardial myofibrils in myocardial dystrophy caused by diffuse endocrine disorders, e. g. hypothyrosis. Cis374 axial distance in Ca-actin filament protomer increased in hypoth...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2007-05, Vol.143 (5), p.587-589
Hauptverfasser:	Sukoyan, G V, Berberashvili, T M, Asatiani, K Dzh
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - chemistry Actins - metabolism Actins - physiology Animals Female Hypothyroidism - metabolism Hypothyroidism - physiopathology Male Myocardium - metabolism Naphthalenesulfonates Rats
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Zusammenfassung:	Fluorescence resonance energy transfer study revealed decreased intermonomer mobility of Ca-actin and Mg-actin filaments of myocardial myofibrils in myocardial dystrophy caused by diffuse endocrine disorders, e. g. hypothyrosis. Cis374 axial distance in Ca-actin filament protomer increased in hypothyrosis. Intracellular pH has no effect on inter-monomer mobility of Ca-actin filament.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-007-0187-7