CD34+AC133+ Cells Isolated from Cord Blood are Highly Enriched in Long‐Term Culture‐Initiating Cells, NOD/SCID‐Repopulating Cells and Dendritic Cell Progenitors

The AC133 antigen is a novel antigen selectively expressed on a subset of CD34+ cells in human fetal liver, bone marrow, and blood as demonstrated by flow cytometric analyses. In this study, we have further assessed the expression of AC133 on CD34+ cells in hemopoietic samples and found that there w...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 1998-11, Vol.16 (6), p.387-396
Hauptverfasser:	de Wynter, E. A., Buck, D., Hart, C., Heywood, R., Coutinho, L. H., Clayton, A., Rafferty, J. A., Burt, D., Guenechea, G., Bueren, J. A., Gagen, D., Fairbairn, L. J., Lord, B. I., Testa, N. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 AC133 Antigen Animals Antigens, CD Antigens, CD34 CD34+ cells Cell Culture Techniques Dendritic cells Dendritic Cells - cytology Fetal Blood - cytology Flow Cytometry Glycoproteins - physiology Hematopoiesis - physiology Hematopoietic Stem Cells - cytology Humans LTC‐IC Mice Mice, Inbred NOD Mice, SCID NOD/SCID mice Peptides - physiology Time Factors
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Zusammenfassung:	The AC133 antigen is a novel antigen selectively expressed on a subset of CD34+ cells in human fetal liver, bone marrow, and blood as demonstrated by flow cytometric analyses. In this study, we have further assessed the expression of AC133 on CD34+ cells in hemopoietic samples and found that there was a highly significant difference between normal bone marrow and cord blood versus aphereses (p
ISSN:	1066-5099 1549-4918
DOI:	10.1002/stem.160387