L-proline as a nitrogen source increases the susceptibility of Saccharomyces cerevisiae S288c to fluconazole

Fluconazole inhibition of Saccharomyces cerevisiae S288c growth was evaluated in media containing ammonia, L-proline or L-leucine as a nitrogen source. Growth inhibition by fluconazole was maximum when L-proline was used as a nitrogen source, while rhodamine 6G accumulation and fluconazole resistanc...

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Veröffentlicht in:	Folia microbiologica 1998, Vol.43 (4), p.403-405
Hauptverfasser:	STELLA, C, COSTANZO, R, BURGOS, H. I, SAENZ, D, VENERUS, R. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - pharmacology Biological and medical sciences Culture Media Drug Resistance, Microbial Fluconazole - pharmacology Medical sciences Microbial Sensitivity Tests Nitrogen - metabolism Pharmacology. Drug treatments Proline - metabolism Rhodamines - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - growth & development
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Zusammenfassung:	Fluconazole inhibition of Saccharomyces cerevisiae S288c growth was evaluated in media containing ammonia, L-proline or L-leucine as a nitrogen source. Growth inhibition by fluconazole was maximum when L-proline was used as a nitrogen source, while rhodamine 6G accumulation and fluconazole resistance were the highest when ammonia was the sole nitrogen source.
ISSN:	0015-5632 1874-9356
DOI:	10.1007/BF02818581