Structure-activity relationship of triterpenes and triterpenoid glycosides against tobacco mosaic virus

Abstract A new activity of triterpenes and triterpenoid glycosides against phytovirus has been found. Based on the anti-TMV replication activity IN VIVO, 47 triterpenes and triterpenoid glycosides were screened through the leaf-disk method together with indirect ELISA. Structure-activity relationshi...

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Veröffentlicht in:	Planta medica 2007-11, Vol.73 (14), p.1457-1463
Hauptverfasser:	Zhang, Z.K, Ouyang, M.A, Wu, Z.J, Lin, Q.Y, Xie, L.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Antiviral Agents - pharmacology antiviral properties Biological and medical sciences General pharmacology glycosides Glycosides - chemistry Glycosides - pharmacology Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology Pharmacology. Drug treatments plant viruses Structure-Activity Relationship structure-activity relationships Tobacco mosaic virus Tobacco Mosaic Virus - drug effects Triterpenes - chemistry Triterpenes - pharmacology triterpenoids virus replication
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Beschreibung
Zusammenfassung:	Abstract A new activity of triterpenes and triterpenoid glycosides against phytovirus has been found. Based on the anti-TMV replication activity IN VIVO, 47 triterpenes and triterpenoid glycosides were screened through the leaf-disk method together with indirect ELISA. Structure-activity relationships were analyzed according to the results of bio-activity screening. Besides, the EC 50 values of those compounds having higher activities were measured.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2007-990263