Effects of intense exercise training on endothelium-dependent exercise-induced vasodilatation

To determine whether intense exercise training affects exercise‐induced vasodilatation, six subjects underwent 4 weeks of handgrip training at 70% of maximal voluntary contraction. Exercise forearm vascular conductance (FVC) responses to an endothelium‐dependent vasodilator (acetylcholine, ACH; 15, 30, 60 μg min−1) and an endothelium‐independent vasodilator (sodium nitroprusside, SNP; 1·6, 3·2, 6·4 μg min−1) and FVC after 10 min of forearm ischaemia were determined before and after training. Training elicited significant (P