Effect of KW-8232, a Novel Anti-osteoporotic Agent, on Bone Loss in Sciatic Neurectomized Rats

The purpose of this study was to evaluate the effects of 3-[bis(4-hydroxyphenyl)methyl]-2-[4-(2-chlorophenyl)-piperazin-1-ylcarbonyl]-1-(2-dimethylaminoethyl) indole methanesulfonate (KW-8232), a novel anti-osteoporotic agent, on bone loss in neurectomized rats. We also investigated the effect of KW...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1998, Vol.78(2), pp.241-243
Hauptverfasser:	Masako, Uchii, Miyuki, Takashima, Tomomi, Sugiyama, Nobuo, Kosaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - urine Animals Bone Density - drug effects Bone loss Calcium - urine Creatinine - urine Femur - drug effects Femur - innervation Femur - physiopathology Indoles - pharmacology Indoles - therapeutic use KW-8232 Male Mesylates - pharmacology Mesylates - therapeutic use Osteoporosis - prevention & control Phosphates - urine Rats Rats, Sprague-Dawley Sciatic Nerve - physiology Sciatic Nerve - surgery Sciatic neurectomy
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