Effect of KW-8232, a Novel Anti-osteoporotic Agent, on Bone Loss in Sciatic Neurectomized Rats

The purpose of this study was to evaluate the effects of 3-[bis(4-hydroxyphenyl)methyl]-2-[4-(2-chlorophenyl)-piperazin-1-ylcarbonyl]-1-(2-dimethylaminoethyl) indole methanesulfonate (KW-8232), a novel anti-osteoporotic agent, on bone loss in neurectomized rats. We also investigated the effect of KW...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1998, Vol.78(2), pp.241-243
Hauptverfasser:	Masako, Uchii, Miyuki, Takashima, Tomomi, Sugiyama, Nobuo, Kosaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - urine Animals Bone Density - drug effects Bone loss Calcium - urine Creatinine - urine Femur - drug effects Femur - innervation Femur - physiopathology Indoles - pharmacology Indoles - therapeutic use KW-8232 Male Mesylates - pharmacology Mesylates - therapeutic use Osteoporosis - prevention & control Phosphates - urine Rats Rats, Sprague-Dawley Sciatic Nerve - physiology Sciatic Nerve - surgery Sciatic neurectomy
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Zusammenfassung:	The purpose of this study was to evaluate the effects of 3-[bis(4-hydroxyphenyl)methyl]-2-[4-(2-chlorophenyl)-piperazin-1-ylcarbonyl]-1-(2-dimethylaminoethyl) indole methanesulfonate (KW-8232), a novel anti-osteoporotic agent, on bone loss in neurectomized rats. We also investigated the effect of KW-8232 on bone resorption in this animal model. Male Sprague-Dawley rats underwent unilateral hind-limb immobilization by sciatic neurectomy. KW-8232 (3, 10 and 30 mg/kg, p.o.) was effective in inhibiting femoral bone loss. KW-8232 decreased urinary pyridinoline and deoxypyridinoline excretion. These results indicate that KW-8232 effectively prevents the bone loss due to immobilization.
ISSN:	0021-5198 1347-3506
DOI:	10.1254/jjp.78.241