Microsome-mediated transformation of O-methylandrocymbine to demecolcine and colchicine

Microsomal preparations from immature seeds of Colchicum autumnale L. catalyse the ring expansion reaction of O-methylandrocymbine to demecolcine in the presence of NADPH and O 2. In addition evidence is given for further transformation of demecolcine to colchicine in the presence of acetyl-CoA and...

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Veröffentlicht in:	FEBS letters 1998-10, Vol.438 (1), p.111-113
Hauptverfasser:	Rueffer, Martina, Zenk, Meinhart H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - metabolism Carbon Monoxide - metabolism Chromatography, Thin Layer Colchicine - biosynthesis Colchicum - enzymology Colchicum autumnale Cytochrome P-450 Enzyme System - metabolism Demecolcine Demecolcine - biosynthesis Hydrogen-Ion Concentration Light Microsomes - metabolism NADP - metabolism Nitrogen - metabolism Oxygen - metabolism Plants, Medicinal Ring expansion reaction Seeds - enzymology Solvents
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Beschreibung
Zusammenfassung:	Microsomal preparations from immature seeds of Colchicum autumnale L. catalyse the ring expansion reaction of O-methylandrocymbine to demecolcine in the presence of NADPH and O 2. In addition evidence is given for further transformation of demecolcine to colchicine in the presence of acetyl-CoA and NADPH.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/S0014-5793(98)01282-4