Drug Delivery of Antisense Molecules to the Brain for Treatment of Alzheimer’s Disease and Cerebral AIDS

Antisense oligonucleotides (ODNs) and peptide nucleic acids (PNAs) are potential therapeutics for eradication of malignancies, viral infections, and other pathologies. However, ODNs and PNAs in general are unable to cross cellular membranes and blood–tissue barriers, such as the blood–brain barrier...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1998-11, Vol.87 (11), p.1308-1315
Hauptverfasser:	Boado, Ruben J., Tsukamoto, Haruhisa, Pardridge, William M.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Dementia Complex - metabolism AIDS Dementia Complex - therapy AIDS/HIV Alzheimer Disease - metabolism Alzheimer Disease - therapy Antibodies, Monoclonal Biological and medical sciences Biotechnology Brain - metabolism Drug Carriers Drug Delivery Systems Fundamental and applied biological sciences. Psychology Gene therapy Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - pharmacokinetics Streptavidin
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Beschreibung
Zusammenfassung:	Antisense oligonucleotides (ODNs) and peptide nucleic acids (PNAs) are potential therapeutics for eradication of malignancies, viral infections, and other pathologies. However, ODNs and PNAs in general are unable to cross cellular membranes and blood–tissue barriers, such as the blood–brain barrier (BBB), which is only permeable to lipophilic molecules of molecular weight
ISSN:	0022-3549 1520-6017
DOI:	10.1021/js9800836