6-Arylamino-5,8-quinolinediones and 7-arylamino-5,8-isoquinolinediones as inhibitors of endothelium-dependent vasorelaxation

6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b, 3f, 4b, 4d and 4g strongly inhibited the va...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-09, Vol.9 (17), p.2469-2472
Hauptverfasser:	Ryu, Chung-Kyu, Jung, Sung-Hee, Lee, Joung-Ah, Kim, Hwa-Jung, Lee, Soo-Hwan, Chung, Jin-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - physiology Biological and medical sciences Cardiovascular system Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Medical sciences Miscellaneous Muscle Relaxation - drug effects Pharmacology. Drug treatments Quinolines - chemical synthesis Quinolines - chemistry Quinolines - pharmacology Rats Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	6-Arylamino-5,8-quinolinediones 3 and 7-arylamino-5,8-isoquinolinediones 4 were synthesized as inhibitors of endothelium-dependent vasorelaxation. The quinones inhibited the vasorelaxation of rat aorta with the endothelium. Among them, the quinones 3a, 3b, 3f, 4b, 4d and 4g strongly inhibited the vasorelaxation.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00411-4