Increased expression of dopamine receptors on lymphocytes in Parkinson's disease

Dopamine D1‐like and D2‐like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjects (multiple‐system atrophy, n = 16; essential tremor, n = 10; other neurodegenerative diseases, n = 10), and...

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Veröffentlicht in:	Movement disorders 1999-09, Vol.14 (5), p.764-771
Hauptverfasser:	Barbanti, Piero, Fabbrini, Giovanni, Ricci, Alberto, Cerbo, Rosanna, Bronzetti, Elena, Caronti, Brunella, Calderaro, Caterina, Felici, Laura, Stocchi, Fabrizio, Meco, Giuseppe, Amenta, Francesco, Lenzi, Gian Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antiparkinson Agents - therapeutic use Binding, Competitive - physiology Biological and medical sciences Brain - pathology Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine Agonists - pharmacokinetics Dopamine receptor Female Humans Levodopa - therapeutic use Lymphocyte Lymphocytes - metabolism Magnetic Resonance Imaging Male Medical sciences Middle Aged Neurology Parkinson Disease - diagnosis Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Radioligand Assay Receptors, Dopamine - metabolism Sensitivity and Specificity Treatment Outcome
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Zusammenfassung:	Dopamine D1‐like and D2‐like receptors on peripheral blood lymphocytes (PBL) were assayed in 50 de novo patients with idiopathic Parkinson's disease (PD), in 36 neurologic control subjects (multiple‐system atrophy, n = 16; essential tremor, n = 10; other neurodegenerative diseases, n = 10), and in 26 healthy control subjects by radioligand binding assay techniques using [3H]SCH 23390 and [3H]7OH‐DPAT as ligands. Patients with PD revealed a higher density (Bmax) of dopamine D1‐like (p
ISSN:	0885-3185 1531-8257
DOI:	10.1002/1531-8257(199909)14:5<764::AID-MDS1008>3.0.CO;2-W