Sympathoinhibitory function of the alpha(2A)-adrenergic receptor subtype

Presynaptic alpha(2)-adrenergic receptors (alpha(2)-AR) are distributed throughout the central nervous system and are highly concentrated in the brain stem, where they contribute to neural baroreflex control of blood pressure (BP). To explore the role of the alpha(2A)-AR subtype in this function, we...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1999-09, Vol.34 (3), p.403-407
Hauptverfasser:	Makaritsis, K P, Johns, C, Gavras, I, Altman, J D, Handy, D E, Bresnahan, M R, Gavras, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Blood Pressure - physiology Body Weight Catecholamines - metabolism Heart Rate - physiology Hypertension - genetics Hypertension - physiopathology Mice Mice, Knockout Receptors, Adrenergic, alpha-2 - genetics Receptors, Adrenergic, alpha-2 - physiology Sodium Chloride - pharmacology
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Zusammenfassung:	Presynaptic alpha(2)-adrenergic receptors (alpha(2)-AR) are distributed throughout the central nervous system and are highly concentrated in the brain stem, where they contribute to neural baroreflex control of blood pressure (BP). To explore the role of the alpha(2A)-AR subtype in this function, we compared BP and plasma norepinephrine and epinephrine levels in genetically engineered mice with deleted alpha(2A)-AR gene to their wild-type controls. At baseline, the alpha(2A)-AR gene knockouts (n=11) versus controls (n=10) had higher systolic BP (123+/-2.5 versus 115+/-2.5 mm Hg, P
ISSN:	0194-911X
DOI:	10.1161/01.HYP.34.3.403