Hypothalamic neuropeptide Y content and mRNA expression in weanling rats subjected to dietary manipulations during fetal and neonatal life

Hypothalamic neuropeptide Y (NPY) is present very early during the fetal life and is rapidly functional in the regulation of feeding behavior after birth. In the present experiment, we tried to determine the influence that the diet type ingested by dams during gestation and lactation would have on t...

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Veröffentlicht in:	Regulatory peptides 1998-09, Vol.75, p.397-402
Hauptverfasser:	Kozak, R, Mercer, J.G, Burlet, A, Moar, K.M, Burlet, C, Beck, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Animals, Suckling Arcuate to paraventricular nuclei axis Blood Glucose - metabolism Body Weight Brain - metabolism Diet Eating Female Fetus - metabolism Food intake Gene Expression High-fat/high carbohydrate diets Hypothalamus - metabolism Insulin Insulin - blood Male Maternal-Fetal Exchange Neuropeptide Y - genetics Neuropeptide Y - metabolism Pregnancy Rats RNA, Messenger - genetics RNA, Messenger - metabolism Tissue Distribution Ventromedian nucleus
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Zusammenfassung:	Hypothalamic neuropeptide Y (NPY) is present very early during the fetal life and is rapidly functional in the regulation of feeding behavior after birth. In the present experiment, we tried to determine the influence that the diet type ingested by dams during gestation and lactation would have on the growth and hypothalamic and pancreatic peptides of their progeny immediately after weaning. The dams were fed on either a high-carbohydrate (HC), a high-fat (HF) or a control diet ad libitum. At 3 days of age, the HC pups weighed significantly more than the two other groups ( P
ISSN:	0167-0115 1873-1686
DOI:	10.1016/S0167-0115(98)00094-9