Developmental changes in purinergic calcium signalling in rat neocortical neurones

The changes in cytoplasm free calcium concentration ([Ca 2+] i transients) were measured in Fura-2/AM loaded pyramidal neurones of sensorimotor cortex in acutely prepared slices isolated from 14 days (P14) and 30 (P30) days old rats. Ni 2+ (50 μM) diminished the [Ca 2+] i transients evoked by 50 mM...

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Veröffentlicht in:	Brain research. Developmental brain research 1998-11, Vol.111 (1), p.43-50
Hauptverfasser:	Lalo, Ulyana, Kostyuk, Platon
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Animals, Newborn - growth & development Animals, Newborn - physiology Caffeine - pharmacology Calcium Channels - physiology Calcium Signaling - drug effects Calcium Signaling - physiology Cell Membrane - metabolism Cerebral Cortex - cytology Cerebral Cortex - physiology Intracellular calcium store Neurons - physiology Plasmalemmal channel Purines - metabolism Purinoreceptor Pyramidal neocortical neuron Rat brain slice Rats Receptors, Purinergic - physiology
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Zusammenfassung:	The changes in cytoplasm free calcium concentration ([Ca 2+] i transients) were measured in Fura-2/AM loaded pyramidal neurones of sensorimotor cortex in acutely prepared slices isolated from 14 days (P14) and 30 (P30) days old rats. Ni 2+ (50 μM) diminished the [Ca 2+] i transients evoked by 50 mM KCl bath application by 47%±8% in neurones of the P14 group and only by 15%±6% in those of P30 group ( P
ISSN:	0165-3806
DOI:	10.1016/S0165-3806(98)00120-5