Triterpene Trimers from Maytenus scutioides: Cycloaddition Compounds?

Two novel trimers, triscutins A and B (1 and 2), based on pristimerin triterpene units, were isolated and characterized from Maytenus scutioides. Their structures were determined on the basis of spectroscopic evidence, including 1H−13C heteronuclear correlation (HMQC), long-range correlation with in...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1999-08, Vol.62 (8), p.1185-1187
Hauptverfasser:	González, Antonio G, Alvarenga, Nelson L, Bazzocchi, Isabel L, Ravelo, Angel G, Moujir, Laila
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Infective Agents - isolation & purification Anti-Infective Agents - pharmacology antimicrobial agents Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Bacteria - drug effects bark Biological and medical sciences Candida - drug effects Candida albicans carcinoma cell lines cervix chemical constituents of plants chemical structure Circular Dichroism cytotoxic compounds Drug Screening Assays, Antitumor General pharmacology Gram-negative bacteria Gram-positive bacteria HeLa Cells hep-2 cell lines Humans larynx Magnetic Resonance Spectroscopy Maytenus Medical sciences medicinal plants metabolites Microbial Sensitivity Tests Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry roots South America spectral analysis triscutins Triterpenes - isolation & purification Triterpenes - pharmacology triterpenoids Tumor Cells, Cultured
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Zusammenfassung:	Two novel trimers, triscutins A and B (1 and 2), based on pristimerin triterpene units, were isolated and characterized from Maytenus scutioides. Their structures were determined on the basis of spectroscopic evidence, including 1H−13C heteronuclear correlation (HMQC), long-range correlation with inverse detection (HMBC), and ROESY NMR experiments; and their absolute configurations, by means of CD studies. Compounds 1 and 2 were assayed for antimicrobial and cytotoxic activities, and their possible biosynthetic route is proposed.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9900728