The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes

The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes

Thirteen neuropeptide Y (NPY) agonists were administered intracerebroventricularly (icv) in rats (full dose–response curves) to estimate their half-effective dose (ED 50) on feeding. These values were compared to their binding affinities (IC 50) for rat NPY receptor subtypes Y1, Y2, Y4 and Y5 in vit...

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Veröffentlicht in:Regulatory peptides 1998-09, Vol.75, p.363-371
Hauptverfasser: Wyss, P, Stricker-Krongrad, A, Brunner, L, Miller, J, Crossthwaite, A, Whitebread, S, Criscione, L
Format: Artikel
Sprache:eng
Schlagworte:
Agonist
Animals
Cell Line
Dose-Response Relationship, Drug
Eating - drug effects
Eating - physiology
Eating disorders
Food Deprivation - physiology
Food intake
Humans
Hyperphagia
Injections, Intraventricular
Male
Neuropeptide Y - administration & dosage
Neuropeptide Y - agonists
Neuropeptide Y - physiology
Obesity
Peptides
Rats
Rats, Sprague-Dawley
Receptors, Neuropeptide Y - classification
Receptors, Neuropeptide Y - drug effects
Receptors, Neuropeptide Y - genetics
Receptors, Neuropeptide Y - physiology
Transfection
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Zusammenfassung:Thirteen neuropeptide Y (NPY) agonists were administered intracerebroventricularly (icv) in rats (full dose–response curves) to estimate their half-effective dose (ED 50) on feeding. These values were compared to their binding affinities (IC 50) for rat NPY receptor subtypes Y1, Y2, Y4 and Y5 in vitro. Correlations between in vivo ED 50 and in vitro IC 50 were strong for the Y5 ( r=0.87; P
ISSN:0167-0115
1873-1686
DOI:10.1016/S0167-0115(98)00089-5