Analysis of Rate of Change of IS6110 RFLP Patterns of Mycobacterium tuberculosis Based on Serial Patient Isolates

Analysis of Rate of Change of IS6110 RFLP Patterns of Mycobacterium tuberculosis Based on Serial Patient Isolates

The rate of change of IS6110 restriction fragment length polymorphism (RFLP) patterns of Mycobacterium tuberculosis was determined in serial isolates from 544 patients. In 25 patients (4.6%), the RFLP patterns of the follow-up isolates differed from the initial isolates. Patients with different foll...

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Veröffentlicht in:The Journal of infectious diseases 1999-10, Vol.180 (4), p.1238-1244
Hauptverfasser: de Boer, Annette S., Borgdorff, Martien W., de Haas, Petra E. W., Nagelkerke, Nico J. D., van Embden, Jan D. A., van Soolingen, Dick
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aged, 80 and over
Bacteriology
Biological and medical sciences
Disease transmission
DNA
DNA Transposable Elements
Epidemiology
Female
Fundamental and applied biological sciences. Psychology
Genetic Variation
Half lives
Humans
Infections
Major Articles
Male
Microbiology
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - genetics
Mycobacterium tuberculosis - isolation & purification
National Institutes of Health (U.S.)
Netherlands
Polymorphism, Restriction Fragment Length
Pulmonary tuberculosis
Rates of change
Restriction fragment length polymorphism
Survival analysis
Tuberculosis
Tuberculosis - microbiology
Tuberculosis, Pulmonary - microbiology
United States
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Zusammenfassung:The rate of change of IS6110 restriction fragment length polymorphism (RFLP) patterns of Mycobacterium tuberculosis was determined in serial isolates from 544 patients. In 25 patients (4.6%), the RFLP patterns of the follow-up isolates differed from the initial isolates. Patients with different follow-up strains were less likely to cluster with patients whose strains had indistinguishable RFLP patterns. Changes in RFLP patterns were more common for persons with extrapulmonary disease and for those who had both pulmonary and extrapulmonary isolates. Based on serial isolates spanning for the most part
ISSN:0022-1899
1537-6613
DOI:10.1086/314979