Chemokine Receptor Polymorphisms and Human Immunodeficiency Virus Disease Progression

The role of polymorphisms in genes encoding chemokines and their receptors (CCR2B, SDF-1, and the promoter region of CCR5) in human immunodeficiency virus (HIV) disease progression was studied in 132 white HIV type 1 (HlV-l)-infected participants from a United Kingdom cohort study. Genotyping was do...

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Veröffentlicht in:	The Journal of infectious diseases 1999-10, Vol.180 (4), p.1096-1105
Hauptverfasser:	Easterbrook, Philippa J., Rostron, Tim, Ives, Natalie, Troop, Maxine, Gazzard, Brian G., Rowland-Jones, Sarah L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS AIDS/HIV Alleles Biological and medical sciences Bisexuality Case-Control Studies CCR2b protein CCR5 protein Confidence Intervals Disease Progression DNA Primers Epidemiology Fundamental and applied biological sciences. Psychology Genetic mutation Genotype Genotypes HIV HIV 1 HIV Antibodies - blood HIV infections HIV Infections - genetics HIV Infections - immunology HIV Infections - physiopathology Homosexuality, Male Human immunodeficiency virus 1 Human viral diseases Humans Infections Infectious diseases Major Articles Male Medical sciences Microbiology Nucleotides Point Mutation Polymerase Chain Reaction Polymorphism, Genetic Prognosis Promoter Regions, Genetic Proportional Hazards Models Receptors, CCR2 Receptors, CCR5 - genetics Receptors, Chemokine - genetics Receptors, Cytokine - genetics SDF-1 protein Time Factors Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
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Zusammenfassung:	The role of polymorphisms in genes encoding chemokines and their receptors (CCR2B, SDF-1, and the promoter region of CCR5) in human immunodeficiency virus (HIV) disease progression was studied in 132 white HIV type 1 (HlV-l)-infected participants from a United Kingdom cohort study. Genotyping was done by use of amplification refractory mutation system-polymerase chain reaction with sequence-specific primers, and Cox proportional hazards models were used to examine the impact of polymorphisms on time to a CD4 cell count
ISSN:	0022-1899 1537-6613
DOI:	10.1086/314997