Differential effect of lithium on 5-HT1 receptor-linked system in regions of rat brain
The effect of chronic administration (0.4% for 30 days) of lithium carbonate (Li2CO3) on 5-HT1 receptor-linked second messenger system was studied in regions of rat brain. We observed that chronic treatment of Li2CO3, significantly decreased the density of [3H]5-HT binding sites in cortex (62%), hip...
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Veröffentlicht in: | Neurochemistry international 1999-10, Vol.35 (4), p.337-343 |
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Sprache: | eng |
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Zusammenfassung: | The effect of chronic administration (0.4% for 30 days) of lithium carbonate (Li2CO3) on 5-HT1 receptor-linked second messenger system was studied in regions of rat brain. We observed that chronic treatment of Li2CO3, significantly decreased the density of [3H]5-HT binding sites in cortex (62%), hippocampus (64%) and striatum (65%), compared to the control levels. The affinity of [3H]5-HT to 5-HT1 binding sites was significantly decreased in all the regions. A significant decrease in the density of high affinity 5-HT1A receptor sites was observed in cortex (81%) and hippocampus (42%), without change in the affinity of [3H]8-OH-DPAT for 5-HT1A sites in these regions. 5-HT-stimulated, but not basal, adenylyl cyclase activity was significantly increased in all the regions after Li treatment. The present study concludes that the increase in the 5-HT-stimulated adenylyl cyclase activity might be attributed to the functional downregulation of 5-HT1 receptors, as these are negatively coupled to adenylyl cyclase, suggesting the involvement of 5-HT1 receptor mediated response in the therapeutic efficacy of lithium. |
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ISSN: | 0197-0186 1872-9754 |
DOI: | 10.1016/S0197-0186(99)00079-0 |