Ethanol Modulation of Excitatory and Inhibitory Synaptic Interactions in Cultured Cortical Neurons

The effects of ethanol on spontaneous excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) were studied in a culture of embryonic rat cortical neurons. In these experiments, EPSCs and IPSCs were recorded concurrently as inward and outward currents, respectively. These spontaneous curren...

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Veröffentlicht in:	Alcoholism, clinical and experimental research clinical and experimental research, 1998-10, Vol.22 (7), p.1516-1524
Hauptverfasser:	Marszalec, William, Aistrup, Gary L., Narahashi, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Cells, Cultured Cerebral Cortex - drug effects Embryo, Mammalian Ethanol Ethanol - pharmacology Excitatory Postsynaptic Current Female GABA Inhibitory Postsynaptic Current Medical sciences Membrane Potentials - drug effects Neural Inhibition - drug effects Neurons - drug effects NMDA Pregnancy Rats Rats, Sprague-Dawley Receptors, GABA - drug effects Receptors, N-Methyl-D-Aspartate - drug effects Synaptic Transmission - drug effects Toxicology
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Zusammenfassung:	The effects of ethanol on spontaneous excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) were studied in a culture of embryonic rat cortical neurons. In these experiments, EPSCs and IPSCs were recorded concurrently as inward and outward currents, respectively. These spontaneous currents were dominated by a slow (
ISSN:	0145-6008 1530-0277
DOI:	10.1111/j.1530-0277.1998.tb03944.x