Structure-based design and synthesis of a novel class of Src SH2 inhibitors

The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2. The structure-based design and synthesis of a novel cla...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 1999-08, Vol.9 (16), p.2353-2358
Hauptverfasser: Buchanan, John L., Bohacek, Regine S., Luke, George P., Hatada, Marcos, Lu, Xiaode, Dalgarno, David C., Narula, Surinder S., Yuan, Ruth, Holt, Dennis A.
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container_end_page 2358
container_issue 16
container_start_page 2353
container_title Bioorganic & medicinal chemistry letters
container_volume 9
creator Buchanan, John L.
Bohacek, Regine S.
Luke, George P.
Hatada, Marcos
Lu, Xiaode
Dalgarno, David C.
Narula, Surinder S.
Yuan, Ruth
Holt, Dennis A.
description The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2. The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.
doi_str_mv 10.1016/S0960-894X(99)00388-1
format Article
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source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Antineoplastic agents
Biological and medical sciences
Crystallography, X-Ray
General aspects
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Pharmacology. Drug treatments
src Homology Domains
Thiazoles - chemical synthesis
Thiazoles - chemistry
Thiazoles - pharmacology
title Structure-based design and synthesis of a novel class of Src SH2 inhibitors
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