Structure-based design and synthesis of a novel class of Src SH2 inhibitors

The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2. The structure-based design and synthesis of a novel cla...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-08, Vol.9 (16), p.2353-2358
Hauptverfasser:	Buchanan, John L., Bohacek, Regine S., Luke, George P., Hatada, Marcos, Lu, Xiaode, Dalgarno, David C., Narula, Surinder S., Yuan, Ruth, Holt, Dennis A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Crystallography, X-Ray General aspects Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacology. Drug treatments src Homology Domains Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology
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Beschreibung
Zusammenfassung:	The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2. The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00388-1