Structure-activity relationship at the proximal phenyl group in a series of non-peptidyl N-type calcium channel antagonists

Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers. SAR at the proximal phenyl group in a series of non-p...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-08, Vol.9 (16), p.2453-2458
Hauptverfasser:	Ryder, Todd R., Hu, Lain-Yen, Rafferty, Michael F., Lotarski, Susan M., Rock, David M., Stoehr, Sally J., Taylor, Charles P., Weber, Mark L., Miljanich, George P., Millerman, Elizabeth, Szoke, Balazs G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Amino Acid Sequence Aniline Compounds - chemistry Aniline Compounds - pharmacology Aniline Compounds - therapeutic use Animals Biological and medical sciences Calcium Channel Blockers - chemistry Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Leucine - analogs & derivatives Leucine - chemistry Leucine - pharmacology Leucine - therapeutic use Medical sciences Mice Mice, Inbred DBA Miscellaneous Molecular Sequence Data Neuropharmacology Pharmacology. Drug treatments Seizures - drug therapy Seizures - physiopathology Structure-Activity Relationship
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Zusammenfassung:	Selective N-Type Voltage Sensitive Calcium Channel (VSCC) antagonists have shown utility in several models of pain and ischemia. We report the structure-activity relationship at the proximal phenyl group in a series of non-peptidyl VSCC blockers. SAR at the proximal phenyl group in a series of non-peptidyl voltage sensitive calcium channel blockers is presented.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00405-9