Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study
OBJECTIVE To clarify controversies on the prevalence and clinical significance of thyroid autoimmunity in hepatitis C virus (HCV) infection. DESIGN A prospective controlled and follow‐up study. PATIENTS AND MEASUREMENTS Serum thyroid microsomal antibody (TMA) and thyroid stimulating hormone were ass...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 1999-04, Vol.50 (4), p.503-509 |
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| creator | Huang, Miau-Ju Tsai, Sun-Lung Huang, Bie-Yu Sheen, I-Shyan Yeh, Chau-Ting Liaw, Yun-Fan |
| description | OBJECTIVE
To clarify controversies on the prevalence and clinical significance of thyroid autoimmunity in hepatitis C virus (HCV) infection.
DESIGN
A prospective controlled and follow‐up study.
PATIENTS AND MEASUREMENTS
Serum thyroid microsomal antibody (TMA) and thyroid stimulating hormone were assayed and compared in a consecutive, unselected series of 130 patients with chronic HCV infection, 130 sex/age (± 2 years)‐matched patients with chronic hepatitis B virus (HBV) infection and 260 matched normal controls.
RESULTS
The prevalence of thyroid autoantibodies in male patients with chronic HCV was |
| doi_str_mv | 10.1046/j.1365-2265.1999.00686.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70017490</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70017490</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4586-52ed6225ea269346e05a7146f5ba1fd27dba06bc62740274763e6b2259aa71143</originalsourceid><addsrcrecordid>eNqNkd-O1CAUxhujccfVVzDEGO9aoS1QjDdm3F1NxnUvNF4SSk8dxg7MAp2deQWfWmonq_HKCwIcft_5w5dliOCC4Jq93hSkYjQvS0YLIoQoMGYNKw4PssX9w8NsgSuMc8xYfZY9CWGDMaYN5o-zsylJIwhZZD9vPOzVAFYDUrZDwXy3pjdaTQHXo7g-emc6pMbolI2mdZ2BgIxFOxUN2BjQnYlrpNfeWaPRGqZ4NAEt0d74cUJ70NE4-wYptPMu7KbrHpB2Nno3DJCqxrE7Ps0e9WoI8Oy0n2dfLy--LD_kq89XH5fvVrmuacNyWkLHypKCKpmoagaYKk5q1tNWkb4redcqzFrNSl7jtDirgLVJIFTiSF2dZ6_mvKmZ2xFClFsTNAyDsuDGIDnGhNcCJ_DFP-DGjd6m3iQRDedY0CpBzQzpNFrw0MudN1vlj5JgOf2z3MjJEzl5Iiez5G-z5CFJn5_yj-0Wur-EszsJeHkCVNBq6H1yxYQ_XBqQ8DJhb2fszgxw_O_6cnlxnQ5Jns9yEyIc7uXK_5CMV5zKb9dX8nJ1814I_EnS6he0_MAw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198770953</pqid></control><display><type>article</type><title>Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Huang, Miau-Ju ; Tsai, Sun-Lung ; Huang, Bie-Yu ; Sheen, I-Shyan ; Yeh, Chau-Ting ; Liaw, Yun-Fan</creator><creatorcontrib>Huang, Miau-Ju ; Tsai, Sun-Lung ; Huang, Bie-Yu ; Sheen, I-Shyan ; Yeh, Chau-Ting ; Liaw, Yun-Fan</creatorcontrib><description>OBJECTIVE
To clarify controversies on the prevalence and clinical significance of thyroid autoimmunity in hepatitis C virus (HCV) infection.
DESIGN
A prospective controlled and follow‐up study.
PATIENTS AND MEASUREMENTS
Serum thyroid microsomal antibody (TMA) and thyroid stimulating hormone were assayed and compared in a consecutive, unselected series of 130 patients with chronic HCV infection, 130 sex/age (± 2 years)‐matched patients with chronic hepatitis B virus (HBV) infection and 260 matched normal controls.
RESULTS
The prevalence of thyroid autoantibodies in male patients with chronic HCV was < 2%. The prevalence of TMA (< 1 : 400) in female patients with chronic HCV infection was significantly higher than that of HBV controls (22.1 vs. 1.6%; P < 0.001), and higher but not significant compared with normal controls (13.5%). However, the trend of increasing prevalence with age in normal controls was not observed in HCV patients. TMA seropositive female HCV patients were not different from seronegative counterparts in age, duration of infection, HLA haplotype, associated autoantibodies and liver histology but had a significantly higher prevalence of genotype 1b/2b mixed infection (P < 0.01) and anti‐GOR (P < 0.05). Of the 23 HCV patients seropositive for thyroid autoantibodies, seven had Hashimoto's thyroiditis, two had Graves' disease and three had received subtotal thyroidectomy. During follow‐up, four of 15 female patients showed a 14–16‐fold increase in TMA titre and one developed hyperthyroidism. Patients with thyroid autoantibodies did not show a propensity to develop thyroid dysfunction during interferon therapy.
CONCLUSIONS
These results suggest a weak association between HCV and thyroid autoimmunity in females. As in the ordinary population with thyroid autoantibodies, they should be evaluated for thyroid status and be followed‐up if thyroid autoimmunity is evident. However, seropositivity of thyroid autoantibodies is not a contraindication to interferon therapy.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1046/j.1365-2265.1999.00686.x</identifier><identifier>PMID: 10468911</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford BSL: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Antiviral Agents - therapeutic use ; Autoantibodies - blood ; Biological and medical sciences ; Case-Control Studies ; Female ; Hepatitis B, Chronic - immunology ; Hepatitis C, Chronic - immunology ; Hepatitis C, Chronic - therapy ; Human viral diseases ; Humans ; Infectious diseases ; Interferon-alpha - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Prevalence ; Thyroglobulin - immunology ; Thyrotropin - blood ; Viral diseases ; Viral hepatitis</subject><ispartof>Clinical endocrinology (Oxford), 1999-04, Vol.50 (4), p.503-509</ispartof><rights>Blackwell Science Ltd, Oxford</rights><rights>1999 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Apr 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4586-52ed6225ea269346e05a7146f5ba1fd27dba06bc62740274763e6b2259aa71143</citedby><cites>FETCH-LOGICAL-c4586-52ed6225ea269346e05a7146f5ba1fd27dba06bc62740274763e6b2259aa71143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2265.1999.00686.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2265.1999.00686.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1740172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10468911$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Miau-Ju</creatorcontrib><creatorcontrib>Tsai, Sun-Lung</creatorcontrib><creatorcontrib>Huang, Bie-Yu</creatorcontrib><creatorcontrib>Sheen, I-Shyan</creatorcontrib><creatorcontrib>Yeh, Chau-Ting</creatorcontrib><creatorcontrib>Liaw, Yun-Fan</creatorcontrib><title>Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clinical Endocrinology</addtitle><description>OBJECTIVE
To clarify controversies on the prevalence and clinical significance of thyroid autoimmunity in hepatitis C virus (HCV) infection.
DESIGN
A prospective controlled and follow‐up study.
PATIENTS AND MEASUREMENTS
Serum thyroid microsomal antibody (TMA) and thyroid stimulating hormone were assayed and compared in a consecutive, unselected series of 130 patients with chronic HCV infection, 130 sex/age (± 2 years)‐matched patients with chronic hepatitis B virus (HBV) infection and 260 matched normal controls.
RESULTS
The prevalence of thyroid autoantibodies in male patients with chronic HCV was < 2%. The prevalence of TMA (< 1 : 400) in female patients with chronic HCV infection was significantly higher than that of HBV controls (22.1 vs. 1.6%; P < 0.001), and higher but not significant compared with normal controls (13.5%). However, the trend of increasing prevalence with age in normal controls was not observed in HCV patients. TMA seropositive female HCV patients were not different from seronegative counterparts in age, duration of infection, HLA haplotype, associated autoantibodies and liver histology but had a significantly higher prevalence of genotype 1b/2b mixed infection (P < 0.01) and anti‐GOR (P < 0.05). Of the 23 HCV patients seropositive for thyroid autoantibodies, seven had Hashimoto's thyroiditis, two had Graves' disease and three had received subtotal thyroidectomy. During follow‐up, four of 15 female patients showed a 14–16‐fold increase in TMA titre and one developed hyperthyroidism. Patients with thyroid autoantibodies did not show a propensity to develop thyroid dysfunction during interferon therapy.
CONCLUSIONS
These results suggest a weak association between HCV and thyroid autoimmunity in females. As in the ordinary population with thyroid autoantibodies, they should be evaluated for thyroid status and be followed‐up if thyroid autoimmunity is evident. However, seropositivity of thyroid autoantibodies is not a contraindication to interferon therapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Hepatitis B, Chronic - immunology</subject><subject>Hepatitis C, Chronic - immunology</subject><subject>Hepatitis C, Chronic - therapy</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interferon-alpha - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Thyroglobulin - immunology</subject><subject>Thyrotropin - blood</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd-O1CAUxhujccfVVzDEGO9aoS1QjDdm3F1NxnUvNF4SSk8dxg7MAp2deQWfWmonq_HKCwIcft_5w5dliOCC4Jq93hSkYjQvS0YLIoQoMGYNKw4PssX9w8NsgSuMc8xYfZY9CWGDMaYN5o-zsylJIwhZZD9vPOzVAFYDUrZDwXy3pjdaTQHXo7g-emc6pMbolI2mdZ2BgIxFOxUN2BjQnYlrpNfeWaPRGqZ4NAEt0d74cUJ70NE4-wYptPMu7KbrHpB2Nno3DJCqxrE7Ps0e9WoI8Oy0n2dfLy--LD_kq89XH5fvVrmuacNyWkLHypKCKpmoagaYKk5q1tNWkb4redcqzFrNSl7jtDirgLVJIFTiSF2dZ6_mvKmZ2xFClFsTNAyDsuDGIDnGhNcCJ_DFP-DGjd6m3iQRDedY0CpBzQzpNFrw0MudN1vlj5JgOf2z3MjJEzl5Iiez5G-z5CFJn5_yj-0Wur-EszsJeHkCVNBq6H1yxYQ_XBqQ8DJhb2fszgxw_O_6cnlxnQ5Jns9yEyIc7uXK_5CMV5zKb9dX8nJ1814I_EnS6he0_MAw</recordid><startdate>199904</startdate><enddate>199904</enddate><creator>Huang, Miau-Ju</creator><creator>Tsai, Sun-Lung</creator><creator>Huang, Bie-Yu</creator><creator>Sheen, I-Shyan</creator><creator>Yeh, Chau-Ting</creator><creator>Liaw, Yun-Fan</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>199904</creationdate><title>Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study</title><author>Huang, Miau-Ju ; Tsai, Sun-Lung ; Huang, Bie-Yu ; Sheen, I-Shyan ; Yeh, Chau-Ting ; Liaw, Yun-Fan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4586-52ed6225ea269346e05a7146f5ba1fd27dba06bc62740274763e6b2259aa71143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Hepatitis B, Chronic - immunology</topic><topic>Hepatitis C, Chronic - immunology</topic><topic>Hepatitis C, Chronic - therapy</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interferon-alpha - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Thyroglobulin - immunology</topic><topic>Thyrotropin - blood</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Miau-Ju</creatorcontrib><creatorcontrib>Tsai, Sun-Lung</creatorcontrib><creatorcontrib>Huang, Bie-Yu</creatorcontrib><creatorcontrib>Sheen, I-Shyan</creatorcontrib><creatorcontrib>Yeh, Chau-Ting</creatorcontrib><creatorcontrib>Liaw, Yun-Fan</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Miau-Ju</au><au>Tsai, Sun-Lung</au><au>Huang, Bie-Yu</au><au>Sheen, I-Shyan</au><au>Yeh, Chau-Ting</au><au>Liaw, Yun-Fan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clinical Endocrinology</addtitle><date>1999-04</date><risdate>1999</risdate><volume>50</volume><issue>4</issue><spage>503</spage><epage>509</epage><pages>503-509</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>OBJECTIVE
To clarify controversies on the prevalence and clinical significance of thyroid autoimmunity in hepatitis C virus (HCV) infection.
DESIGN
A prospective controlled and follow‐up study.
PATIENTS AND MEASUREMENTS
Serum thyroid microsomal antibody (TMA) and thyroid stimulating hormone were assayed and compared in a consecutive, unselected series of 130 patients with chronic HCV infection, 130 sex/age (± 2 years)‐matched patients with chronic hepatitis B virus (HBV) infection and 260 matched normal controls.
RESULTS
The prevalence of thyroid autoantibodies in male patients with chronic HCV was < 2%. The prevalence of TMA (< 1 : 400) in female patients with chronic HCV infection was significantly higher than that of HBV controls (22.1 vs. 1.6%; P < 0.001), and higher but not significant compared with normal controls (13.5%). However, the trend of increasing prevalence with age in normal controls was not observed in HCV patients. TMA seropositive female HCV patients were not different from seronegative counterparts in age, duration of infection, HLA haplotype, associated autoantibodies and liver histology but had a significantly higher prevalence of genotype 1b/2b mixed infection (P < 0.01) and anti‐GOR (P < 0.05). Of the 23 HCV patients seropositive for thyroid autoantibodies, seven had Hashimoto's thyroiditis, two had Graves' disease and three had received subtotal thyroidectomy. During follow‐up, four of 15 female patients showed a 14–16‐fold increase in TMA titre and one developed hyperthyroidism. Patients with thyroid autoantibodies did not show a propensity to develop thyroid dysfunction during interferon therapy.
CONCLUSIONS
These results suggest a weak association between HCV and thyroid autoimmunity in females. As in the ordinary population with thyroid autoantibodies, they should be evaluated for thyroid status and be followed‐up if thyroid autoimmunity is evident. However, seropositivity of thyroid autoantibodies is not a contraindication to interferon therapy.</abstract><cop>Oxford BSL</cop><pub>Blackwell Science Ltd</pub><pmid>10468911</pmid><doi>10.1046/j.1365-2265.1999.00686.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 1999-04, Vol.50 (4), p.503-509 |
| issn | 0300-0664 1365-2265 |
| language | eng |
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| subjects | Adult Aged Antiviral Agents - therapeutic use Autoantibodies - blood Biological and medical sciences Case-Control Studies Female Hepatitis B, Chronic - immunology Hepatitis C, Chronic - immunology Hepatitis C, Chronic - therapy Human viral diseases Humans Infectious diseases Interferon-alpha - therapeutic use Male Medical sciences Middle Aged Prevalence Thyroglobulin - immunology Thyrotropin - blood Viral diseases Viral hepatitis |
| title | Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study |
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