Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study

OBJECTIVE To clarify controversies on the prevalence and clinical significance of thyroid autoimmunity in hepatitis C virus (HCV) infection. DESIGN A prospective controlled and follow‐up study. PATIENTS AND MEASUREMENTS Serum thyroid microsomal antibody (TMA) and thyroid stimulating hormone were ass...

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Veröffentlicht in:	Clinical endocrinology (Oxford) 1999-04, Vol.50 (4), p.503-509
Hauptverfasser:	Huang, Miau-Ju, Tsai, Sun-Lung, Huang, Bie-Yu, Sheen, I-Shyan, Yeh, Chau-Ting, Liaw, Yun-Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antiviral Agents - therapeutic use Autoantibodies - blood Biological and medical sciences Case-Control Studies Female Hepatitis B, Chronic - immunology Hepatitis C, Chronic - immunology Hepatitis C, Chronic - therapy Human viral diseases Humans Infectious diseases Interferon-alpha - therapeutic use Male Medical sciences Middle Aged Prevalence Thyroglobulin - immunology Thyrotropin - blood Viral diseases Viral hepatitis
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Zusammenfassung:	OBJECTIVE To clarify controversies on the prevalence and clinical significance of thyroid autoimmunity in hepatitis C virus (HCV) infection. DESIGN A prospective controlled and follow‐up study. PATIENTS AND MEASUREMENTS Serum thyroid microsomal antibody (TMA) and thyroid stimulating hormone were assayed and compared in a consecutive, unselected series of 130 patients with chronic HCV infection, 130 sex/age (± 2 years)‐matched patients with chronic hepatitis B virus (HBV) infection and 260 matched normal controls. RESULTS The prevalence of thyroid autoantibodies in male patients with chronic HCV was
ISSN:	0300-0664 1365-2265
DOI:	10.1046/j.1365-2265.1999.00686.x