Progesterone-Induced Blocking Factor Inhibits Degranulation of Natural Killer Cells

PROBLEM: During the first trimester of pregnancy, nonclassical (CD3—, CD56+, CD16—, perforin [P]bright +) natural killer (NK) cells comprise the major decidual lymphocyte population. These cells, in spite of their high perforin content, exert a low cytolytic activity. Peripheral blood lymphocytes of...

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Veröffentlicht in:	American journal of reproductive immunology (1989) 1999-08, Vol.42 (2), p.71-75
Hauptverfasser:	Faust, Zs, Laškarin, G., Rukavina, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences CD56 Antigen - biosynthesis Cell Degranulation - immunology Cells, Cultured Cytoplasmic Granules - immunology Cytoplasmic Granules - metabolism Decidua Decidua - cytology Decidua - immunology Decidua - metabolism degranulation Female Fundamental and applied biological sciences. Psychology Humans Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Activation - immunology Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - secretion Mother. Fetoplacental unit. Mammary gland. Milk NK cells Perforin PIBF Pore Forming Cytotoxic Proteins Pregnancy Pregnancy Proteins - biosynthesis Pregnancy Proteins - physiology Pregnancy. Parturition. Lactation progesterone Suppressor Factors, Immunologic - pharmacology Vertebrates: reproduction
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