Genomic Structure and Chromosomal Localization of the Human Cathepsin O Gene (CTSO)

The human gene encoding cathepsin O, a cysteine proteinase from the papain superfamily, has been cloned and its overall organization established. The gene (HGMW-approved symbolCTSO) is composed of eight coding exons and seven introns and spans more than 30 kb. The number and distribution of exons an...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1998-10, Vol.53 (2), p.231-234
Hauptverfasser:	Santamarı&́a, Iñigo, Pendás, Alberto M., Velasco, Gloria, López-Otı&́n, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cathepsin K Cathepsins - genetics Chromosomes, Human, Pair 4 Cloning, Molecular Exons Fundamental and applied biological sciences. Psychology Genes. Genome Humans In Situ Hybridization, Fluorescence Introns Molecular and cellular biology Molecular genetics Restriction Mapping
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Beschreibung
Zusammenfassung:	The human gene encoding cathepsin O, a cysteine proteinase from the papain superfamily, has been cloned and its overall organization established. The gene (HGMW-approved symbolCTSO) is composed of eight coding exons and seven introns and spans more than 30 kb. The number and distribution of exons and introns differ from those reported for other human cysteine proteinases, indicating that these genes are not closely related. Chromosomal localization ofCTSOrevealed that it maps to chromosome 4q31–q32, which is a unique location for all cysteine proteinases mapped to date.
ISSN:	0888-7543 1089-8646
DOI:	10.1006/geno.1997.5180