The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma
Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to n...
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| Veröffentlicht in: | Cancer letters 1999-08, Vol.143 (1), p.29-35 |
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| container_title | Cancer letters |
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| creator | Leonardos, L Butler, L.M Hewett, P.J Zalewski, P.D Cowled, P.A |
| description | Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to normal mucosa (
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| doi_str_mv | 10.1016/S0304-3835(99)00176-7 |
| format | Article |
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P<0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (
P<0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/S0304-3835(99)00176-7</identifier><identifier>PMID: 10465334</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adenoma - enzymology ; Adenoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Amino Acid Chloromethyl Ketones - pharmacology ; Apoptosis ; Biological and medical sciences ; Carcinoma - enzymology ; Carcinoma - pathology ; Caspase 3 ; Caspase Inhibitors ; Caspases - metabolism ; Colorectal carcinoma ; Colorectal Neoplasms - enzymology ; Colorectal Neoplasms - pathology ; Coumarins ; Cysteine Proteinase Inhibitors - pharmacology ; Enzyme Precursors - antagonists & inhibitors ; Enzyme Precursors - metabolism ; Female ; Fluorescence ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Intestinal Mucosa - enzymology ; Jurkat Cells - enzymology ; Male ; Medical sciences ; Middle Aged ; Oligopeptides ; Protease ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Cancer letters, 1999-08, Vol.143 (1), p.29-35</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-5edc76ed41b1d20d39e47efb5ca6f59320106382217fc2c8681ddb10afd03d563</citedby><cites>FETCH-LOGICAL-c390t-5edc76ed41b1d20d39e47efb5ca6f59320106382217fc2c8681ddb10afd03d563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3835(99)00176-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1924473$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10465334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leonardos, L</creatorcontrib><creatorcontrib>Butler, L.M</creatorcontrib><creatorcontrib>Hewett, P.J</creatorcontrib><creatorcontrib>Zalewski, P.D</creatorcontrib><creatorcontrib>Cowled, P.A</creatorcontrib><title>The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to normal mucosa (
P<0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (
P<0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis.</description><subject>Adenoma - enzymology</subject><subject>Adenoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amino Acid Chloromethyl Ketones - pharmacology</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - enzymology</subject><subject>Carcinoma - pathology</subject><subject>Caspase 3</subject><subject>Caspase Inhibitors</subject><subject>Caspases - metabolism</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - enzymology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Coumarins</subject><subject>Cysteine Proteinase Inhibitors - pharmacology</subject><subject>Enzyme Precursors - antagonists & inhibitors</subject><subject>Enzyme Precursors - metabolism</subject><subject>Female</subject><subject>Fluorescence</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Jurkat Cells - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oligopeptides</subject><subject>Protease</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFTEUhoNY7LX6E5RZiOhi9GQySSarIqWthUIX1nXITc5obGZym-Re6L9v7ge2u64OB573PYeHkA8UvlGg4vsvYNC3bGD8i1JfAagUrXxFFnSQXSvVAK_J4j9yTN7m_A8AeC_5G3JMoRecsX5B7O1fbIwtfuPLQxPHxpq8Mhlb1gZ_h80qxYJ1z43PDQbcmIKucevk5z9NqVmHGwxxNeFcdvEYYkJbTKhNyfo5TuYdORpNyPj-ME_I74vz27Of7fXN5dXZj-vWMgWl5eisFOh6uqSuA8cU9hLHJbdGjFyxDigINnQdlaPt7CAG6tySghkdMMcFOyGf97316fs15qInny2GYGaM66xlFUCZGCrI96BNMeeEo14lP5n0oCnorV29s6u36rRSemdXy5r7eDiwXk7onqX2Oivw6QCYbE0Yk5mtz0-c6vpesoqd7jGsNjYek87W42zR-a077aJ_4ZNH1eaXJw</recordid><startdate>19990823</startdate><enddate>19990823</enddate><creator>Leonardos, L</creator><creator>Butler, L.M</creator><creator>Hewett, P.J</creator><creator>Zalewski, P.D</creator><creator>Cowled, P.A</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990823</creationdate><title>The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma</title><author>Leonardos, L ; Butler, L.M ; Hewett, P.J ; Zalewski, P.D ; Cowled, P.A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-5edc76ed41b1d20d39e47efb5ca6f59320106382217fc2c8681ddb10afd03d563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adenoma - enzymology</topic><topic>Adenoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amino Acid Chloromethyl Ketones - pharmacology</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - enzymology</topic><topic>Carcinoma - pathology</topic><topic>Caspase 3</topic><topic>Caspase Inhibitors</topic><topic>Caspases - metabolism</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - enzymology</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Coumarins</topic><topic>Cysteine Proteinase Inhibitors - pharmacology</topic><topic>Enzyme Precursors - antagonists & inhibitors</topic><topic>Enzyme Precursors - metabolism</topic><topic>Female</topic><topic>Fluorescence</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Jurkat Cells - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oligopeptides</topic><topic>Protease</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leonardos, L</creatorcontrib><creatorcontrib>Butler, L.M</creatorcontrib><creatorcontrib>Hewett, P.J</creatorcontrib><creatorcontrib>Zalewski, P.D</creatorcontrib><creatorcontrib>Cowled, P.A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leonardos, L</au><au>Butler, L.M</au><au>Hewett, P.J</au><au>Zalewski, P.D</au><au>Cowled, P.A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1999-08-23</date><risdate>1999</risdate><volume>143</volume><issue>1</issue><spage>29</spage><epage>35</epage><pages>29-35</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to normal mucosa (
P<0.0001). Caspase-3-like activity was much higher in normal mucosa and tumours of female subjects than of males (
P<0.0001). No correlation was obtained between caspase-3-like activity and location of the tumour, tumour grade, stage, or patient age. The marked increase in caspase-3-like activity in colorectal carcinomas may reflect an increase in the proportion of cells undergoing spontaneous apoptosis.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10465334</pmid><doi>10.1016/S0304-3835(99)00176-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cancer letters, 1999-08, Vol.143 (1), p.29-35 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adenoma - enzymology Adenoma - pathology Adult Aged Aged, 80 and over Amino Acid Chloromethyl Ketones - pharmacology Apoptosis Biological and medical sciences Carcinoma - enzymology Carcinoma - pathology Caspase 3 Caspase Inhibitors Caspases - metabolism Colorectal carcinoma Colorectal Neoplasms - enzymology Colorectal Neoplasms - pathology Coumarins Cysteine Proteinase Inhibitors - pharmacology Enzyme Precursors - antagonists & inhibitors Enzyme Precursors - metabolism Female Fluorescence Gastroenterology. Liver. Pancreas. Abdomen Humans Intestinal Mucosa - enzymology Jurkat Cells - enzymology Male Medical sciences Middle Aged Oligopeptides Protease Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma |
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