The activity of caspase-3-like proteases is elevated during the development of colorectal carcinoma

Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to n...

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Veröffentlicht in:	Cancer letters 1999-08, Vol.143 (1), p.29-35
Hauptverfasser:	Leonardos, L, Butler, L.M, Hewett, P.J, Zalewski, P.D, Cowled, P.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - enzymology Adenoma - pathology Adult Aged Aged, 80 and over Amino Acid Chloromethyl Ketones - pharmacology Apoptosis Biological and medical sciences Carcinoma - enzymology Carcinoma - pathology Caspase 3 Caspase Inhibitors Caspases - metabolism Colorectal carcinoma Colorectal Neoplasms - enzymology Colorectal Neoplasms - pathology Coumarins Cysteine Proteinase Inhibitors - pharmacology Enzyme Precursors - antagonists & inhibitors Enzyme Precursors - metabolism Female Fluorescence Gastroenterology. Liver. Pancreas. Abdomen Humans Intestinal Mucosa - enzymology Jurkat Cells - enzymology Male Medical sciences Middle Aged Oligopeptides Protease Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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Zusammenfassung:	Activated caspase-3-like proteases promote apoptotic cell death by cleaving cellular substrates. Caspase-3-like activity was measured in colonic carcinomas and in matched normal colonic mucosa from 31 patients and was significantly elevated in 25/31 colonic carcinomas and adenomas when compared to normal mucosa ( P
ISSN:	0304-3835 1872-7980
DOI:	10.1016/S0304-3835(99)00176-7