Histologic studies of the effects of circulating hot saline on the uterus before hysterectomy

Abstract Study Objective. To evaluate a new device for endometrial ablation. Design. (Canadian Task Force classification II-1). Setting. University-affiliated hospital. Patients. Thirty-two women scheduled for hysterectomy. Interventions. Endometrial ablation and hysterectomy. Measurements and Main Results. The new device for endometrial ablation was evaluated by studying depth of necrosis after staining for the oxidative enzyme NADH. Uniform endomyometrial necrosis was achieved at a depth of 2 to 4 mm with 90°C saline circulated for 10 minutes. Conclusion. The procedure was successful in all patients, and there were no adverse clinical sequelae.