Induction of inhibitory antibodies to the CCR5 chemokine receptor and their complementary role in preventing SIV infection in macaques

The seven‐transmembrane G‐protein‐linked CCR5 molecule functions as a major coreceptor for HIV or simian immunodeficiency virus (SIV) infection. Antibodies to CCR5 were studied in rhesus macaques immunized with SIV grown in human CD4+ T cells. These macaques were completely protected against i.v. ch...

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Veröffentlicht in:	European journal of immunology 1999-08, Vol.29 (8), p.2427-2435
Hauptverfasser:	Lehner, Thomas, Wang, Yufei, Doyle, Carl, Tao, Louisa, Bergmeier, Lesley A., Mitchell, Elaine, Bogers, Willy M. J. M., Heeney, Jonathan, Kelly, Charles G.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antibodies, Monoclonal Antibody Antibody Formation CCR5 CCR5 protein CD4-Positive T-Lymphocytes - immunology Cell Line Chemotaxis, Leukocyte - immunology Humans Immunization Immunoglobulin G - blood In Vitro Techniques Macaca mulatta Primate Receptors, CCR5 - genetics Receptors, CCR5 - immunology Receptors, HIV - immunology Receptors, Virus - immunology Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - pathogenicity Simian Immunodeficiency Virus - physiology Transfection Vaccine Virus Replication
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Zusammenfassung:	The seven‐transmembrane G‐protein‐linked CCR5 molecule functions as a major coreceptor for HIV or simian immunodeficiency virus (SIV) infection. Antibodies to CCR5 were studied in rhesus macaques immunized with SIV grown in human CD4+ T cells. These macaques were completely protected against i.v. challenge with live SIV. Sera from the protected macaques showed significantly greater inhibition of SIV replication (p
ISSN:	0014-2980 1521-4141
DOI:	10.1002/(SICI)1521-4141(199908)29:08<2427::AID-IMMU2427>3.0.CO;2-5