T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease

Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in...

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Veröffentlicht in:Immunology today (Amsterdam. Regular ed.) 1998-10, Vol.19 (10), p.468-473
Hauptverfasser: Salojin, Konstantin V., Zhang, Jian, Madrenas, Joaquin, Delovitch, Terry L.
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Sprache:eng
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Zusammenfassung:Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease.
ISSN:0167-5699
DOI:10.1016/S0167-5699(98)01326-7