T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease
Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in...
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Veröffentlicht in: | Immunology today (Amsterdam. Regular ed.) 1998-10, Vol.19 (10), p.468-473 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease. |
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ISSN: | 0167-5699 |
DOI: | 10.1016/S0167-5699(98)01326-7 |