Assignment of the Steroid Receptor Coactivator-1 (SRC-1) Gene to Human Chromosome Band 2p23

Nuclear receptor coactivators (NRCoAs) mediate the ligand- dependent transcriptional activation of specific genes by nuclear receptors, for example, the receptors for steroid and thyroid hormones, retinoids, and vitamin D. Currently, three NRCoAs have been cloned: TIF2 (also known as GRIP1 or NCoA-2), SRC-1 (also known as F-SRC-1 or NCoA-1) , and AIB1 (also known as RAC3, ACTR, or p/CIP). Several lines of evidence have implicated abnormalities of NRCoAs in malignancy. Here we have mapped the chromosomal localization of SRC-1 (GenBank Accession No. U40396) to determine whether this gene is also located at a region that has been implicated in malignancy. Translocations involving chromosome 2p23 or neighboring bands have been reported in a variety of hematological malignancies. The mapping of SRC-1 to 2p23 provides a further candidate gene for disruption by these translocations.